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Ranking the best hangover cure of 2022

Last updated: April 16, 2022

Hangover cureswhile they act more as preventatives, and are not guaranteed to cure a hangoverare an essential if you drink alcohol regularly.

They’re especially useful if you plan to drink more alcohol than usual. Hangovers occur for a variety of reasons, including alcohol toxicity, dehydration, inflammation, and changes in your nutrient status that can occur as a result of heavy drinking.

However, by far the factors that play the largest role in presence and severity of a hangover are how much alcohol you drink, your alcohol tolerance, and your size in relation to these things.

Hangover cures contain ingredients that support your liver function, that help you break down alcohol more quickly, and that may help replenish your fluid and nutrient losses during drinking. Here are our top 10 recommendations for the best hangover cure.


1. Purple Tree Celebration

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Purple Tree provides a potent blend of B-complex vitamins for energy, DHM and milk thistle for liver function, and a range of antioxidants and trace minerals for fighting hangover-induced inflammation. It’s a great all-around formulation that addresses both the mental and physical manifestations of a hangover, which is why we’ve chosen it for our top spot.

2. NatureNetics LiverSmart

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NatureNetics takes pride in producing high-quality supplements. This LiverSmart blend contains milk thistle extract, which may be a powerful way to boost your liver health. It also contains other ingredients that can support your liver before and after drinking alcohol, like dandelion root, artichoke leaf, yellow dock root, protease, and beet root.

Although it’s not labeled as a hangover cure or preventative, it has many positive reviews regarding its benefits for hangover prevention. Its liver support ingredients may help your body to better be able to detoxify from alcohol.

Additionally, NatureNetics ensures that all of their supplements are third-party tested for purity, quality, and accuracy of label claims by not one company, but multiple third-party testing labs.

3. DHM Depot Dihydromyricetin

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Dihydromyricetin is a compound isolated from the Hovenia dulcis, or Japanese raisin tree. It is a unique compound that may help prevent hangovers or potentially lessen their severity. It can be taken before, during, or after drinking alcohol to help prevent or improve hangovers by helping your liver to process alcohol more efficiently.

This dihydromyricetin supplement from DHM Depot is third-party tested to assure quality, and made using high-quality, pharmaceutical grade dihydromyricetin.

4. Jarrow Formulas Milk Thistle

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Although this milk thistle supplement from Jarrow Formulas is not specifically made for hangover prevention, milk thistle does have some beneficial effects on the liver that may make it a great hangover preventative. Additionally, this product has some positive reviews from people who have used it for hangover prevention.

Jarrow Formulas labs complete multiple rounds of testing to ensure the quality of their supplements, and they are produced in a GMP-certified facility.

5. Cheers Restore Capsules

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Cheers Restore Capsules work by reducing GABA rebound, supporting the liver, and replacing lost vitamins and trace minerals. It uses DHM to support GABA levels to elevate your mood, and a range of natural extracts to support liver function. If the mental side of hangovers hits you harder than the physical side, it’s a great choice.

6. FlyBy Recovery

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FlyBy Recovery is meant to be taken before and after you drink. It contains liver-support ingredients like dihydromyricetin and milk thistle, but also contains a variety of nutrients that may actually be impacted by alcohol consumption. It also contains a number of additional herbs that may keep you feeling your best after a night of drinking.

7. Over EZ Pre Drink Supplement

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Over EZ uses herbs, amino acids, and vitamins like, Milk Thistle, Zinc, Magnesium and Vitamin B  complex to make sure you wake up feeling your best. Take just 1 capsule before or with your first drink for it to work it’s magic.

This supplement has no fillers, binders or preservatives making this an all around great choice.

8. PartySmart

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PartySmart uses a blend of plant extracts including chicory seed, green chiretta, and grape extract to fight oxidative damage and boost alcohol metabolism. While it’s pretty popular, it ends up lower in the rankings because it lacks some of the vitamin and mineral ingredients that can give a more rapid boost to your mood and energy levels.

9. Blowfish for Hangovers

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Blowfish for Hangovers is a very popular post-party supplement, but beyond aspirin and caffeine, it doesn’t provide any additional benefits. Despite its popularity, it’s essentially a headache medicine, which makes it hard to endorse for providing any benefits above and beyond the classic hangover remedy of NSAID (like ibuprofen) and a cup of coffee.

10. Morning Recovery

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Morning Recovery is a liquid shot-style supplement that provides DHM alongside a range of natural extracts including milk thistle, prickly pear, and red ginseng extract. Unfortunately, these extracts are locked up in a proprietary blend, which makes it difficult to ascertain whether these ingredients are delivered at an effective dosage. This lack of clarity lands this supplement at the bottom of the rankings.

Category winners

Best hangover cure overall: Purple Tree Celebration

Purple Tree Celebration has an excellent balance of basic hangover cures, like B-complex vitamins to boost energy levels and support enzyme function, plus more advanced ingredients like DHM and milk thistle that support your mental state and your liver function. The broad range of ingredients with specific, targeted applications makes it our overall winner.

Best hangover cure for liver health: NatureNetics LiverSmart

While no hangover cure can counter the long-term effects of alcohol usage on the liver, NatureNetics LiverSmart provides a range of naturally-sourced extracts like milk thistle extract that support liver function in the short term as you clear out the metabolites of alcohol. 

Best hangover cure with DHM: DHM Depot Dihydromyricetin

DHM, short for dihydromyricetin, is a naturally-sourced compound that acts on neurotransmitter receptors in the brain and on enzymes in the liver. DHM Depot Dihydromyricetin is our favored source of DHM for hangovers thanks to its solid dosage and pure formulation—if you’re following the latest research on DHM for hangovers, this supplement does the best job of matching the research protocols.

Best hangover cure for elevating your mood: Cheers Restore Capsules

Hangover got you feeling down? It shouldn’t be much of a surprise, since hangovers deplete levels of neurotransmitters in your brain that control your mood. Cheers Restore is a great choice if the mental side of being hung over is more of an issue than the typical physical symptoms, since it provides ingredients like DHM, L-cysteine, and ginger extract that are intended to target these depleted neurotransmitters and elevate your mood.

Best fast-acting hangover cure: Purple Tree Celebration

Our top overall pick is also our recommendation for a rapid-acting hangover cure. The B-complex vitamins and trace minerals in Purple Tree Celebration are rapidly absorbed, giving you a jump-start on your post-hangover recovery. 

Best hangover cure with GABA: Cheers Restore Capsules

GABA is a neurotransmitter that is linked to your mood state. Part of the down, depressed, lethargic state of mind that can accompany a hangover may be traced to lower levels of GABA in the brain. Cheers Restore Capsules provide DHM to boost GABA levels specifically to counteract this effect, so if you’re looking for a hangover cure that’s more focused on mental versus physical symptoms, Cheers is a good choice.

Who should buy a hangover cure?

If you know you’re going to have a long night out, or if you find yourself battling headaches, nausea, and lethargy after a night of partying, you’re probably in need of a hangover cure. A supplement that contains compounds to fight these hangover effects, and possibly mitigate some of the deleterious effects of a hangover on liver function, metabolic function, and hormone levels, might be just what you need to feel better after a night of hard drinking. 

Some people even recommend taking hangover cures before you start drinking, with the aim of mitigating the effects of a hangover as early as possible. While the jury is still out on the efficacy of hangover cures taken either before or after a night of drinking, it might be worth a shot given that some ingredients in hangover cures can take several hours to get absorbed into your body. 

If you’re planning on using a hangover cure, you’ll want it on hand before you are actually hung over, since the most acute effects of a hangover don’t last very long, so by the time you pick up a hangover cure and by the time its ingredients start having an effect, you’ll be mostly recovered anyways. So, with hangover cures, plan ahead!

How we ranked

Dietary supplements, unlike medications and food, are not regulated by any kind of government organization or regulating body. Unfortunately, this means that some manufacturers may take advantage of this lack of regulation and lie about what their supplement actually contains in order to cut costs or make more sales.

Luckily, there are a number of third-party testing labs that offer supplement testing to ensure that the manufacturers are making honest claims and using high-quality ingredients in their products. Some of these organizations include NSF International, ConsumerLab, and United States Pharmacopeia (USP).

Our top three supplementsNatureNetics LiverSmart, DHM Depot Dihydromyricetin, and NatureBell Dihydromyricetinhave all underwent this third-party testing process, ensuring that their product is safe and that their manufacturers are honest in labeling and marketing claims.

The next best option to ensure product quality is by seeking out supplements that were manufactured in a GMP- or FDA-approved facility. Although this is not a guarantee of the quality of the supplement, it does mean that the manufacturer is meeting certain rigorous standards in the facility where the supplement is produced.

Finally, the remainder of our rankings were based on the scientific evidence behind certain ingredients. All of the supplements that made this list contain ingredients that have been shown in scientific studies to help prevent hangovers, reduce their severity, or help boost liver function.


Hangover cures may prevent and treat hangovers. The most obvious benefit of a hangover cure is that it may prevent a hangover, or at least decrease the severity of your hangover.

These supplements contain ingredients that may help reverse or prevent the changes to your body that cause hangovers, namely hormonal balance, the toxic effects of alcohol, liver stress, and dehydration.

In animal studies, dihydromyricetinwhich is an ingredient in many hangover curesreduced alcohol consumption and reduced the effect of alcohol on the neurotransmitter GABA. In humans, these changes would hypothetically result in a less severe hangover. However, more research in humans is needed, as most of the current evidence for dihydromyricetin is in animal models (1).

Additionally, silybinwhich is the most biologically active compound in milk thistlehas been demonstrated to help protect the liver. Because alcohol is primarily processed by the liver, milk thistle supplementation may help the process of alcohol detoxification by the liver to be more efficient. This can help decrease the damage done by alcohol to your body, as well as decrease your risk of a hangover (2).

Hangover cures may help rehydrate you. Dehydration is one potential factor contributing to the development of a hangover, as well as the severity of them. Although alcohol is fluid, drinking it to excess can actually cause you to become dehydrated. This is why common advice for hangover prevention includes drinking water before and between alcoholic beverages (3).

Because alcohol is toxic to your body, your liver prioritizes it so that it can get rid of the alcohol quickly. It decreases the action of the hormone vasopressin, which causes your body get rid of more fluid. Because of this, you may urinate more frequently or have a higher volume of urine during or after you’ve drank alcohol. Dehydration occurs when you don’t replace these fluid losses (4).

However, some hangover cures that come in powder form need to be taken with water, which can help decrease your risk of becoming dehydrated. Additionally, nearly all hangover cureseven those in pill formshould be taken with a full glass of water, instead of just a few sips.

Hangover cures may prevent headaches and muscle cramps. Along with dehydration from fluid losses, it is easy for your electrolyte levels to become imbalanced when you’re drinking alcohol. This can lead to headaches and muscle cramps, which are commonly reported with hangovers.

To help alleviate these problems, some hangover cures contain the electrolytes that you may lose due to dehydration, like magnesium, chloride, sodium, and potassium.

Hangover cures may prevent electrolyte and nutrient imbalances. In the short-term, alcohol consumption can affect your electrolyte levels, as discussed above. This can lead to headaches or muscle cramps.

However, chronic alcohol consumption over the long term can also lead to changes in nutrient levels, particularly the B-vitamins, such as thiamin. Thiamin deficiency is a common trait in alcoholism (5).

Many hangover cures contain added nutrients to help mitigate your risk of becoming nutrient deficient. For people who only drink occasionally or who drink in moderation, nutrient deficiency is not a huge risk. However, if you have a drinking problem, a hangover cure will not be enough to protect you from nutrient deficiency. You should seek guidance from a qualified healthcare professional to help you quit drinking and keep you healthy.

Hangover cures may help prevent liver damage as a result of excessive drinking. Alcohol is toxic to your liver. In low doses, it usually doesn’t cause any significant issues, as your liver is able to process it fairly quickly to remove it from your system.

However, excessive drinkingespecially over the long-termcan lead to severe and debilitating liver problems, such as fatty liver disease and liver cirrhosis. Even short-term episodes of binge drinking can cause permanent liver damage.

Although you should avoid binge drinking entirely to maximize your health, some of the herbs and compounds in hangover cures may help your body to metabolize alcohol more efficiently, leading to a decreased risk of liver damage from alcohol consumption. These include dihydromyricetin and milk thistle.

Side effects

Hangover cures may not prevent or cure your hangover. Although they’re generally referred to as “hangover cures,” the best protection that these supplements can offer is the possibility that they can prevent a hangover or make it less severe than it otherwise would be. Taking one of these supplements before or after drinking alcohol is not a guarantee that you won’t have a hangover the next day. Many factors affect if you’ll have a hangover and its severity, like your hydration status, how much alcohol you drink, how much you weigh, and your alcohol toleranceand these are just a few examples.

To help your hangover cure supplement be as effective as possible, you should drink plenty of water while you are drinking alcohol. A good rule of thumb to consider is to have one glass of water between each serving of an alcoholic drink. You should also not drink to extreme excess. Alcohol is toxic to your liver, so your liver prioritizes the detoxification of alcohol when it’s in your system. When there’s a large amount of alcohol in your system, you are more likely to experience a hangover the next day while your body is still struggling to detoxify the alcohol.

Hangover cures may contain allergens. You may be allergic to the ingredients in some hangover cures. You should check the label carefully to see if it contains any of your known allergens before taking it. If you feel like you may be having an allergic reaction to one of these supplements, you should discontinue use immediately and seek medical care.

If you’re allergic to ragweed or other plants in the same family, you may also be allergic to milk thistle – which is a common ingredient in hangover prevention supplements. Use extreme caution and seek a health professional’s advice before using a milk thistle supplement if you’re allergic to ragweed (6).

Hangover cures may contain ingredients that cause complications or that interact with medications. For instance, milk thistlewhich is commonly found in liver support and hangover prevention supplementscan cause digestive problems. It may also decrease your blood sugar levels, which can be dangerous if you’re already taking insulin or a blood sugar-lowering medication (6).

Because many of these hangover cure supplements contain multiple ingredients, this can make it difficult to identify what exactly is causing side effects if you are experiencing them. If you do experience any uncomfortable side effects, you should stop using the supplement.

Recommended usage

Depending on the brand and formulation, hangover cures can be taken before, during, or after drinking alcohol.

Most supplements that are specifically marketed for hangover prevention instruct you to take the supplement after you are finished drinking, but before you go to bed. They may instruct you to double-up on doses or to take one dose before you start drinking too, if it’s going to be a particularly heavy night of drinking.

On the other, other supplements like NatureNetics LiverSmart is meant to be taken with meals, and may be more effective for hangovers if taken with a meal before you start drinking.

It’s important that you follow the manufacturer’s instructions for dosing, which will give you the highest odds of successfully preventing a hangover after drinking.

You should also take your hangover prevention supplements with a glass of water, and make sure you are drinking plenty of water while drinking alcohol as well. Dehydration may be one of the main causes of a hangover, so if you can stay adequately hydrated before, during, and after drinking you may be able to prevent the worst of a hangover’s effects.


Q: What is a hangover?

A: A hangover is a group of symptoms that typically occurs after an episode of alcohol consumption, especially excessive alcohol consumption. Hangovers affect different people in different ways, but may typically involve grogginess, fatigue, headache, muscle cramps, and generally feeling unwell.

A variety of factors affect the severity of a hangover, or if you will have a hangover at all. The largest factor appears to be the amount of alcohol you drink in relationship to your size and your alcohol tolerance. For example, a larger person who drinks regularly will have a higher alcohol toleranceand a lower risk of hangoverthan a smaller person who doesn’t drink very often.

However, a number of other factors are at play as well. These include brain alterations and cellular dysfunction that occurs as a result of alcohol exposure, as alcohol is toxic to the body. Hangover severity may also be affected by your hydration status, inflammation levels, electrolyte levels, and hormonal balance (3, 7).

Q: What ingredients in hangover cures may help treat or prevent hangovers?

A: There are a number of ingredients in hangover cures that may support liver function and alcohol detoxification. These include:

Milk thistle. Although there’s very little evidence available regarding milk thistle specifically for hangovers, a great deal of evidence exists to support the use of milk thistle for general liver health and improved detoxification of alcohol and other toxins.

Milk thistle is rich in silybin, a flavonoid antioxidant that gives the herb many of its potential health-boosting benefits.

A high-quality study from the 1980s also noted an improvement in liver health after milk thistle supplementation in people with liver disease related to alcohol abuse. Although this research is dated, newer research shows similar findings (8).

In one recent study of children with leukemia and subsequent liver toxicity, supplementing with milk thistle was associated with improvements in markers of liver health and a decrease in toxicity. Although this study was not alcohol-related, it highlights the liver health benefits of milk thistle and silybin (9).

Dihydromyricetin. Although most of the evidence for dihydromyricetin is from animal studies, this evidence offers a promising starting point for future human research. This compound can help reduce alcohol consumption when taken before drinking, and help lessen the short-term effects that alcohol has on your body. It works by dampening some of the effects that alcohol has on your body, particularly on the hormone GABA. GABA is a neurotransmitter that actually blocks nervous system function. After alcohol consumption, GABA usually becomes stronger. However, dihydromyricetin keeps the nervous system functioning optimally without additional interruption from GABA (1).

Prickly pear cactus. One high-quality human study in 64 adults found that prickly pear extract reduced hangover when taken 5 hours before consuming alcohol. Particularly, prickly pear significantly decreased complaints of nausea, dry mouth, and appetite loss. Taking prickly pear also reduced the risk of having a severe hangover by 50 percent (10).

Researchers theorize that this is because prickly pear helped decrease the body’s inflammatory response to alcohol.

N-acetyl-cysteine. N-acetyl-cysteine is another ingredient that is commonly found in hangover cures. It’s a powerful antioxidant that may help reduce inflammation and prevent some of the cellular damage caused by alcohol exposure, which may theoretically help improve a hangover.

Although most of the existing research on N-acetyl-cysteine has been done in animals, the evidence is promising. This antioxidant may help strengthen your liver cells, equipping them to more efficiently process and rid your body of alcohol. Taking N-acetyl-cysteine before drinking may also help prevent alcohol-related reductions to your glutathione levels. Glutathione also acts as an antioxidant that can help prevent cellular damage (11).

Q: How much alcohol does it take to cause a hangover?

A: This varies significantly from person-to-person. Your overall health, size, alcohol tolerance, and the amount you drink in a sitting are all key factors.

As a general rule, you should try to avoid binge drinking. This will likely keep you from experiencing a hangover at all. Moderate drinking is defined as one alcoholic drink per day for a woman, and two alcoholic drinks per day for a man (12).

Q: Why does alcohol in excess harm the liver?

A: Alcohol and its breakdown products are toxic to your body. When alcohol is present, your liver prioritizes alcohol detoxification so that it can remove the toxin from your body as quickly as possible.

Over time, alcohol exposure can damage your liver and lead to fatty liver disease or liver cirrhosis, when sections of your liver essentially die. If you continue to drink in excess, this puts even more strain on the functioning remainder of your liver.

Because your liver also has a number of other responsibilities, like storing nutrients, creating bile, packaging fats, and detoxifying other substances from your body, like medications, the constant cycle of detoxifying alcohol can cause a number of other issues that affect your whole body.

Q: Should I take a hangover cure before or after drinking?

A: Follow the label instructions for the hangover cure that you purchase. Most hangover cures should be taken after you’re finished drinking for the night, but before you go to bed. They may also instruct you to take a dose before drinking if you anticipate that you’ll be drinking more than usual.

Q: What is the best hangover pill?

A: We recommend NatureNetics LiverSmart, which you can buy here, but any of the supplements on our ranking list are solid options. The best hangover pill should contain ingredients that are proven to help boost your liver function, assist with alcohol detoxification, or replenish nutrients that may be lost while your body processes alcohol.

Q: How can you get rid of a hangover fast?

A: Unfortunately, it’s difficult to get rid of a hangover quickly once it has started. The best way to get rid of a hangover is to prevent it completely or decrease its severity by staying well-hydrated while drinking and taking a hangover prevention supplement.

Anecdotally, some people report that taking pain relievers like aspirin or ibuprofen, eating a meal rich in carbohydrates, or drinking a caffeinated drink help them get rid of hangovers quickly. However, there’s little scientific evidence to support these hangover cures.

Q: What are some other ways to help prevent or treat a hangover?

A: The best way to prevent a hangover is to avoid drinking to excess. A general rule of thumb for moderate drinking is that women should stick to one alcoholic beverage per day, while men can have up to two alcoholic drinks per day. While this may not be the best advice for everyone, it covers most people. A single alcoholic beverage is defined as 12 ounces of beer, 5 ounces of wine, or 1.5 ounces of a distilled spirit like whiskey, rum, or vodka (13).

However, you shouldn’t “bank” your drinks and have them all in one night, which may seem tempting. This puts a much greater strain on your liver and will likely lead to a hangover.

If you do plan to drink excessively, you should drink plenty of water during the day leading up to your event. Consider having a glass of water between each alcoholic beverage as well, and eat your meals as normal to ensure that alcohol is not the only substance in your stomach.

Related articles


Hangover cures function primarily as hangover preventatives. They are typically taken after you drink alcohol, and they can help your body process alcohol more efficiently and combat the negative effects of alcohol consumptionideally resulting in no hangover or a significantly less severe hangover for you the next morning.

Some of the ingredients in hangover cures contain a great deal of scientific evidence to support them, especially milk thistle and dihydromyricetin.

For BodyNutrition’s #1 recommended hangover cure, click here.


SaVanna Shoemaker